CORDIS Project
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This project investigates how a single cell, the zygote, achieves totipotency through changes in 3D chromatin organization and the activation of the genome. It focuses on the role of epigenetic reprogramming and transcription factors in establishing the totipotent state, which is crucial for early development in mammal…
One of the most intriguing questions in biology is how a single cell (zygote) is generated that has the potential to give rise to all cell types of an organism, known as totipotency.
The overall purpose of this project is to gain mechanistic insights into the establishment of the totipotent state, in terms of 3D chromatin organization and zygotic genome activation (ZGA), summarized in two key aims:i)To test whether and how epigenetic reprogramming modulates the 3D chromatin structure in zygotes:…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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