CORDIS Project
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This project investigates the process of X-chromosome inactivation in female mammals, focusing on the mechanisms that establish and maintain monoallelic gene expression. By exploring the X-inactivation centre and its role in chromosomal silencing, the research aims to uncover insights into epigenetic regulation and nuc…
X-chromosome inactivation (XCI) represents a classic example of epigenetics in mammals.
In this process, one of the two X chromosomes in females is converted from an active into a clonally heritable, inactive, state during early embryonic development, to ensure dosage compensation between the sexes.
This process is also remarkable in that an entire chromosome is silenced while its homologue, present in the same nucleus, remains active.
Thus, in addition to being an epigenetics paradigm, XCI also…
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