CORDIS Project
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This project investigates the role of mTOR and autophagy in kidney aging using specialized mouse models. It aims to identify epigenetic changes associated with aging and their implications for chronic kidney diseases.
Here, we propose a program to identify the role of mTOR and autophagy dependent epigeneticmodifications during kidney aging.
We have assembled a unique set of complementary mouse models including kidney specific and timely inducible autophagy and mTOR deficient mice.
For the detailed molecular analysis of transgenic podocyte tissue, we have generated a double-labeled transgenic mouse model, where podocytes expressing green fluorescent protein are contrasted by other kidney cells expressing red f…
UNIVERSITAETSKLINIKUM FREIBURG
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