CORDIS Project
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This project investigates the plasticity of adult human nasal chondrocytes derived from cranial neural crest cells, focusing on their potential for cartilage regeneration. It aims to understand the molecular mechanisms that enable these cells to adapt and repair various types of cartilage, including intervertebral disc…
During craniofacial development, Cranial Neural Crest Cells (CNCCs) maintain broad plasticity and patterning competence until they make appropriate cartilage and bone structures in response to local cues.
We found that CNCC embryonic plasticity involves a specific epigenetic chromatin signature that maintains genes, including Hox genes, in a transcriptionally silent but poised state, so that they can be readily switched to an active state in response to position-specific environmental signals. A…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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Switzerland, Basel
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Switzerland, Basel
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SME: No
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