CORDIS Project
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This project investigates how certain viruses, like Chikungunya and SARS-CoV-2, manipulate host cellular machinery to enhance protein production despite using rare codons. It aims to uncover the mechanisms behind this adaptation, focusing on tRNA modification enzymes and their potential as targets for antiviral therapi…
Recent evidence indicates that codon usage bias regulates gene expression, as synonymous codons are not decoded with the same efficiency.
Viruses are entirely dependent on the host translation machinery to express their proteins.
Puzzlingly, the genomes of diverse viruses synthesize viral proteins at high levels, such as those of the emerging Chikungunya virus (CHIKV), dengue virus (DENV) and the pandemic SARS-CoV-2 are enriched in rare codons that should slow down their translation.
How these v…
UNIVERSIDAD POMPEU FABRA
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