CORDIS Project
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This project seeks to develop molecules that can recognize both standard and epigenetic DNA nucleobases, facilitating advancements in cancer research. By creating tools for precise editing of epigenetic markers, it aims to enhance our understanding of gene regulation and cancer dynamics.
Human DNA contains two types of biologically instructive information: the canonical nucleobases A, G, T, C, and the epigenetic nucleobases mC, hmC, fC, and caC.
Canonical nucleobases encode the identity of all RNAs and proteins that are synthesized by a cell, whereas epigenetic nucleobases regulate this synthesis.
This regulation shapes the phenotype of cells, and its perturbation is a key trigger of cancer.Canonical nucleobases can be decoded in a programmable manner by nucleic acids and their…
TECHNISCHE UNIVERSITAT DORTMUND
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