CORDIS Project
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This project aims to develop a detailed model of chromatin fibers to understand how epigenetic modifications influence gene expression. It seeks to clarify the interactions between DNA and histone modifications, which are crucial for chromatin structure and function.
This project will develop a highly sophisticated coarse-grained model of chromatin fibers from precise all-atom simulations of dinucleosomes and DNA segments.
The purpose of the proposed project is to enhance our understanding of the mechanism by which different patterns of epigenetic modifications (of DNA and histone proteins) interact with each other to control the structure of the chromatin fiber and regulate gene expression.
Our modelling strategy will be based on landmark experimental stud…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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