CORDIS Project
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This project investigates the mechanisms behind centromere function and epigenetic inheritance using advanced imaging techniques. By studying the dynamics of specific proteins, the research aims to uncover how epigenetic marks are maintained during cell division.
The centromere is a unique specialized chromatin domain responsible for the nucleation of the kinetochore, a large proteinaceous complex that, during mitosis, powers and controls chromosome movement on spindle microtubules ensuring accurate chromosome segregation, thereby preventing aneuploidy, a major hallmark of human cancers.
Although directly embedded in chromatin no specific DNA sequence is either necessary or sufficient to propagate the centromere which is specified largely in an epigeneti…
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