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EpiCblood focuses on enhancing early cancer detection by analyzing circulating cell-free nucleosomes in blood. It aims to develop methods to identify cancer-specific DNA markers, improving liquid biopsy techniques for better cancer management.
Early cancer detection could increase curative treatment and long-term survival.
Dying cells release small DNA fragments wrapped around a core of histone proteins into the bloodstream, so-called circulating cell-free nucleosomes (cf-nucleosomes).
They carry DNA sequence information and histone modifications stable in blood, reflecting promising epigenomic disease biomarkers.
But, the low proportion of cf-nucleosomes originating from cancerous cells versus the large background of nucleosomes aris…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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