CORDIS Project
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This project investigates how the PIK3CA-H1047R mutation affects breast cancer cell behavior by reactivating multipotency through epigenetic regulators. The goal is to identify new therapeutic targets that can work alongside existing PI3K inhibitors to reduce tumor diversity and combat treatment resistance.
Breast cancer is a heterogeneous disease which is classified into different histological and molecular subgroups presenting different clinical outcomes.
Also, the diversity of genetic/epigenetic alterations in cancer cells and their interactions with the microenvironment enhance cell plasticity and result in intra-tumor heterogeneity.
While tumor heterogeneity is a major hurdle to anti-cancer therapy, its underlying molecular mechanisms remain ill-defined.
The Phosphoinositide 3-kinase (PI3K) pa…
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