CORDIS Project
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This project focuses on understanding the role of epigenetic pathways in cancer by studying chromatin-modifying proteins. It aims to develop tools for systematically investigating these proteins and their impact on cancer cell proliferation and survival.
Epigenetic pathways contribute to cancer development and progression.
These pathways act via proteins that modulate chromatin structure and gene expression, and can thereby give pro-proliferative and anti-apoptotic properties selected for in cancer.
In total ~400 factors are known that either modify chromatin directly as epigenetic ‘writers’ (DNA methyltranserases, histone methyltransferases, acetyltransferases, kinases, ubiquitinases) and ‘erasers’ (histone demethylases, deacetylases, phosphata…
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