CORDIS Project
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The epiC9repair project investigates the genetic mechanisms behind neurodegenerative diseases linked to repeat expansions in the C9orf72 gene. By exploring DNA repair pathways and chromatin changes, the project aims to uncover factors contributing to conditions like amyotrophic lateral sclerosis and frontotemporal deme…
Repeat expansions are a major cause of neurodegenerative diseases, but causal therapies are not available. A (G4C2)n repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in Europe.
Despite extensive research, the mechanisms linking these expansions to selective neurodegeneration remain poorly understood.
Our project, epiC9repair, explores the novel hypothesis that genomic instability at the C9orf72 locus, driven by…
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
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