CORDIS Project
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This project investigates the epigenetic mechanisms governing ageing in the model organism Caenorhabditis elegans. It focuses on the role of the histone H2A-ubiquitin mark in gene regulation and lifespan determination, aiming to identify key enzymes and protein complexes involved in these processes.
Ageing is certainly one of the most interesting but less understood processes of multi-cellular organisms.
Although in the last decade great advances have been made to understand the molecular mechanism of ageing a unifying model is still elusive.
Research in C. elegans has focussed on the characterization of signalling pathways involved in ageing.
It is was demonstrated that the gene expression of old nematodes differs significantly from young worms, however, the molecular mechanisms that gover…
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
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