CORDIS Project
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This project investigates the therapeutic potential of a naturally occurring peptide that inhibits the CXCR4 receptor, which is involved in various diseases, including cancer and inflammation. The goal is to develop improved derivatives for better treatment options.
Deregulation of CXCL12 signaling via the CXCR4 chemokine receptor plays a key role in many diseases, including cancer, rheumatoid arthritis, chronic inflammation and cardiovascular disorders.
Thus, agents modulating CXCR4 signaling offer many prospects for therapeutic development. CXCR4 is also a major coreceptor for HIV entry.
Thus, we used HIV as tool to screen peptide libraries encompassing the entire blood peptidome for novel CXCR4 ligands.
This approach allowed the identification of a small…
UNIVERSITAET ULM
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France, Strasbourg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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