CORDIS Project
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This project explores the regulation of stem cells in the skin and cornea, focusing on the molecular mechanisms that govern their development and maintenance. It aims to create patient-specific stem cell models to advance understanding of genetic diseases and develop new therapeutic strategies.
The stratified epithelium of the skin (epidermis) and the cornea share common characteristics in term of structure, function and developmental origin.
These tissues which line the external surface of the mammalian body and eye are multi-layered tightly packed tissues providing protection against infections, injuries and water loss.
Although skin stem cell therapy have been firstly reported 3 decades ago, in 1984, ex vivo expansion of stem cell and the maintenance of their multi potency is poor.…
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