CORDIS Project
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This project investigates how dying cells influence tissue shape during development, focusing on the Drosophila leg model. It explores the mechanisms of force generation by apoptotic cells and their impact on surrounding tissues, aiming to uncover the genetic and cellular dynamics involved in this process.
Contrary to previous beliefs, recent studies have suggested that apoptotic cells play an important dynamic role during morphogenesis.
Nonetheless, the mechanisms whereby dying cells drive tissue shape modification remain elusive.
Using the Drosophila developing leg as a model system to study apoptosis-dependent epithelium folding, we have recently shown that apoptotic cells produce a pulling force through the unexpected maintenance of their adherens junctions that serves as an anchor to an apic…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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