CORDIS Project
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The project investigates the relationship between obesity and the risk of estrogen receptor-positive breast cancer in postmenopausal women. It focuses on the role of estrone and its impact on inflammatory pathways that may contribute to cancer development.
Observational studies indicate that obesity and the risk of developing estrogen receptor-positive (ER+) breast cancers has an inverse association in premenopausal women, but a positive association in post-menopausal women.
Breast cancer risk rises steeply after menopause, when estradiol decreases markedly and estrone become the major serum estrogen.
Adipose tissue express high levels of the enzyme aromatase, being the major site of estrogen synthesis after menopause.
Obesity in postmenopausal w…
UNIVERSIDAD DE GRANADA
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