CORDIS Project
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This project investigates the toxic effects of Loxosceles spider venom, focusing on the enzyme sphingomyelinase D and its interaction with biological membranes. By utilizing advanced fluorescence techniques and model systems, it aims to elucidate the mechanisms behind venom-induced cellular damage, particularly in red…
Bites from the Loxosceles genus (brown spiders) cause several clinical manifestations in mammals, especially necrotic skin degeneration, hematological disturbances, and renal failure.
These spiders have a world-wide distribution and accidents have been described in America, Europe, Asia, Africa and Oceania.
The venoms of Loxosceles comprise a toxic component with a rare enzymatic activity, termed sphingomyelinase D (SMD).
This enzyme catalyzes the conversion of sphingomyelin (SM) into ceramide-1…
SYDDANSK UNIVERSITET
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