CORDIS Project
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This research aims to uncover the mechanisms of antiviral defense that operate independently of type I and III interferons. It will identify key players and explore the early responses to viral infections at epithelial surfaces.
Virus-induced type I interferons (IFN) have classically been considered to constitute the first line of defense against virus infections However, recent work by us and others has identified early antiviral actions that occur independently of inducible type I and III IFN expression and sometimes even prior to IFN action (e.g.
Iversen,...., Paludan.
Nature Immunology, 2016;
Paludan.
Trends in Immunology, 2016).
These discoveries challenge the current thinking in the field that IFNs constitute the…
AARHUS UNIVERSITET
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