CORDIS Project
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This project investigates the role of the TPR protein in the DNA damage response and its implications for cancer development. It employs advanced proteomic and imaging techniques to understand TPR's function in coordinating DNA repair and maintaining genome stability.
Each cell in the human body receives thousands of DNA lesions per day.
To counteract threats posed by DNA damage, cells have evolved an integrated signaling network called the DNA-damage response (DDR).
This mechanism allows cells to detect DNA lesions, signal their presence and promote their repair.
Mutation of DDR genes, which serves as a biological barrier against tumor progression, leads to cancer development2. A large-scale proteomic analysis of proteins phosphorylated in response to DNA da…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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