CORDIS Project
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This project investigates how the bacterium Shigella flexneri interacts with host cells, focusing on the role of septins in immune defense. By using zebrafish models, it aims to uncover new mechanisms of host defense and cytoskeleton dynamics during bacterial infections.
The intracellular bacterium Shigella flexneri is an exceptional model pathogen to address key issues in biology, including how bacteria can move inside host cells and escape the immune system.
The cytoskeleton has recently emerged to occupy a central role in innate immunity by promoting bacterial sensing and executing antibacterial functions. I discovered that host cells employ septins, a poorly understood component of the cytoskeleton, to restrict the actin-based motility of Shigella and target…
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
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