CORDIS Project
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This project explores the transcriptional regulation and functions of telomeric repeat-containing RNAs (TERRA), which play a critical role in genome stability. By investigating the factors that influence TERRA biogenesis and localization, it aims to enhance understanding of telomere functions and their implications in…
Telomeres, the heterochromatic structures that protect the ends of the chromosomes are transcribed into a novel class of long non-coding RNAs whose transcriptional regulation and functions are unknown.
Telomeres protect the physical extremities of the chromosomes and they are are essential to genome integrity and stability.
Dysfunctional telomeres have been detected in up to 90% of human cancers.
We recently found that telomeres are transcribed from the subtelomeric region towards the end of the…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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