CORDIS Project
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This project investigates how enteroviruses, particularly poliovirus and coxsackievirus B3, replicate within host cells. It focuses on the role of viral protein 2C in assembling viral components on membranes and the function of filamentous proteins in virus-induced autophagy using advanced imaging and biochemical techn…
Enteroviruses (EVs) are positive-sense, single stranded RNA virus from the Picornaviridae family.
With 106 types, they can cause mild to severe diseases in human, especially children, such as common cold (Rhinovirus), myocarditis (Coxsackievirus B3, CVB3) or poliomyelitis (Poliovirus, PV). EVs are known to remodel the cytoplasm of host cells to create replication organelles allowing efficient viral genome replication.
They also hijack the secretory autophagy pathway for replication and viral rel…
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