CORDIS Project
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This project develops a methodology for normalizing imaging mass spectrometry data to enable accurate quantification of proteins in tissue samples. It utilizes isotopically labeled standards to improve the reliability of proteomic analyses.
Imaging Mass Spectrometry is a rapidly developing technique that uses spatially resolved proteomic techniques to investigate a tissue’s biomolecular content.
Imaging MS of pharmaceuticals has demonstrated that relative quantitation can be obtained if the MS response factors are known.
However MS response factors for peptides and proteins are highly dependent on their exact nature.
Despite it being acknowledged as the single biggest factor limiting the clinical application of the technique, to da…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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