CORDIS Project
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The project aims to enhance the process of clearing dying cells in the body, which is vital for reducing inflammation and maintaining health. It explores the use of small molecules to improve the efficiency of this cellular cleanup, potentially leading to new therapies for inflammatory diseases.
Our bodies turn over billions of cells every day to keep us healthy.
Old, damaged or excess cells need to be cleared, and professional and non-professional phagocytes engulf cells dying by apoptosis.
The efficiency of this process is critical for homeostasis, minimising inflammation, and promoting organ function.
Deficiencies in engulfment predispose to autoimmune and inflammatory diseases, and the host lab has shown that mice deficient in molecular components of engulfment exhibit exaggerated i…
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