CORDIS Project
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This project investigates the gene regulatory networks involved in mammalian sex determination, focusing on the roles of transcription factors and enhancers. It aims to develop an in vitro organoid system to model testis development and improve understanding of disorders related to sex development and infertility.
During mammalian sex determination, the bipotential embryonic gonad adopts either testicular or ovarian cell fates.
This process highly relies on precise expression of several pro-male versus pro-female factors, most of which are transcription factors (TFs) and signalling pathway components.
Yet, we still do not understand the interplay and hierarchy among these factors, their direct target genes, the regulatory elements they bind to, nor do we have an in vitro system to address these questions.…
BAR ILAN UNIVERSITY
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