CORDIS Project
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This project focuses on enhancing the regenerative capacity of mammalian neural stem cells by rewiring their gene expression circuits. It aims to identify and utilize synthetic enhancers that activate developmental genes in response to injury, potentially leading to innovative gene therapies for spinal cord repair.
The mammalian central nervous system (CNS) is the epitome of complex cellular architecture.
Still, it has a limited capacity to self-repair after an injury, which contrasts with the regenerative potential of the CNS in lower vertebrates.
Regeneration unfolds by the orchestrated triggering of developmental gene expression programs after injury.
These programs are under the control of dedicated regeneration enhancer elements, which grant adult cells transcriptional access to developmental genes. N…
KAROLINSKA INSTITUTET
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