CORDIS Project
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This project focuses on enhancing the functionality of induced pluripotent stem cell-derived hepatocytes for liver transplantation. It aims to identify factors from the cellular environment that improve their performance in three-dimensional cultures.
Induced pluripotent stem cell derived hepatocytes (i-Heps) afford us the exciting possibility of redressing the growing shortage in liver transplantation tissue and heralding in a new era of patient specific drug and disease modelling.
Clinical applications are restricted by their poor functionality in comparison to the gold standard – freshly isolated primary hepatocytes.
Emerging evidence suggests the three dimensional environment surrounding a cell (the niche) critically influences cellular f…
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