CORDIS Project
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This project investigates the NLRP1 and CARD8 inflammasome sensors, focusing on their unique mechanisms for detecting viral infections. By utilizing advanced genomics and proteomics, it aims to elucidate their roles in antiviral immunity and immune cell regulation, potentially leading to new therapeutic strategies.
Inflammasomes play a pivotal role in host defense.
They function as intracellular surveillance systems by sensing pathogens or indirectly by responding to the perturbation of cellular homeostasis.
While our understanding of inflammasome biology is growing at a rapid pace, we still have an incomplete understanding of how these systems detect pathogenic insults, or how these sensors operate at the molecular level.
Just recently, NLRP1 and the closely related CARD8, a functionally distinct subgroup…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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