CORDIS Project
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This project investigates how bacterial pathogens invade host cells and manipulate cellular environments for survival. By studying the mechanisms of bacterial vacuole integrity, the research aims to identify new therapeutic targets for treating infections.
A common strategy of bacterial pathogens is active or passive uptake into host cells.
There, they can localize within a bacterial containing vacuole (BCV) or access the host cytoplasm through BCV rupture.
Hence, intracellular pathogens are often classified as vacuole-bound or cytoplasmic.
Recently, this definition has been challenged by the discovery that many vacuole-bound pathogens, including Mycobacterium tuberculosis and Salmonella enterica, access the host cytoplasm, and by the insight that…
INSTITUT PASTEUR
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