CORDIS Project
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This project aims to understand the molecular mechanisms behind inflammatory bowel disease by studying the FRMPD2 protein complex. It focuses on its role in immune defense and epithelial cell adhesion, using various biological techniques and models.
Inflammatory bowel disease is a devastating disease affecting several million people in Europe.
This proposal addresses the molecular mechanism of inflammatory bowel disease.
The multi-PDZ domain protein FRMPD2 (FERM and PDZ domain containing protein 2) has been shown to be an integral part of the immune host defense of epithelial cells by recruiting NOD2 (Nucleotide-binding and oligomerization protein 2), a key player of the innate immune system, to the basolateral membrane in epithelial cells.…
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