CORDIS Project
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This project investigates how inflammation alters the metabolism of endothelial cells, contributing to atherosclerosis and cardiovascular disease. By using advanced 3D organ-on-chip models, it aims to understand the effects of these metabolic changes on stem cell function and macrophage activity, ultimately seeking new…
Inflammation is an important driver of atherosclerosis, the primary cause of global morbidity and mortality in emerging and developed countries.
New strategies to reduce atherosclerotic cardiovascular disease (CVD) risk are therefore eagerly needed. I recently found that atherogenic inflammatory stimuli rewire cellular metabolism in endothelial cells (ECs) and thereby contribute to atherosclerosis progression.
Defining the intricate link between EC inflammation, metabolic rewiring and functional…
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