CORDIS Project
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ENDo-HERPES investigates the role of inherited human herpesvirus 6 in disease development. The project aims to understand the functionality of integrated viral genomes and their effects on host cells, particularly focusing on how these viruses may reactivate and contribute to various health conditions.
Endogenous viruses present in the human genome control physiological processes, modulate aging, and can cause diseases.
Intriguingly, a herpesvirus has entered the human germ line by integrating its genome into telomeres of germ cells and is present in about 80 million people.
The virus, human herpesvirus 6 (HHV-6), can reactivate from the integrated state, which is associated with a number of diseases.
These include seizures, encephalitis, heart failure and graft rejection.
We recently analysed…
FREIE UNIVERSITAET BERLIN
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