CORDIS Project
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This project investigates how mechanical properties of the microenvironment influence intestinal stem cells during development and disease. It focuses on the interactions between stem cells and their surrounding niche, particularly in the context of inflammatory disorders like Necrotizing Enterocolitis and colorectal c…
Tissue turnover and regeneration are orchestrated by stem cells that both differentiate and self-renew.
The balance between self-renewal, proliferation, and commitment depends on the stem cell microenvironment, or “niche”.
Importantly, stem cells are not simply passive responders to their niches; instead, they play an integral role in building and communicating with their immediate microenvironment.
Although multiple studies have described the molecular and cellular composition of the niche to d…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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