CORDIS Project
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This project explores the effects of aging on capillary endothelial cells and their role in organ regeneration. Using a mouse model of Hutchinson-Gilford progeria syndrome, it aims to identify mechanisms of age-related dysfunction and develop potential therapies to improve tissue repair and address age-related health i…
Capillary endothelial cells (ECs) are not just passive conduits for delivering blood.
Rather, ECs also play tissue-specific functions by providing highly specialized sets of angiocrine factors that control tissue homeostasis, regulate stem cell self-renewal, and guide organ regeneration without provoking fibrosis.
However, it is not known whether tissue-specific instructive functions of ECs are lost during ageing.
Moreover, the causal role of EC ageing in age-associated tissue dysfunction has no…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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