CORDIS Project
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This project focuses on advancing the study of membrane proteins by developing a new mass spectrometry technique. By preserving the native lipid environment, the research aims to better understand protein-lipid interactions, which are crucial for drug development and biological functions.
Excising a membrane protein from its natural environment, preserving the lipid bilayer, and characterising the lipids that surround it is the ‘holy grail’ of membrane protein biophysics.
However, with some 40,000 different lipid structures the challenges we face in understanding selective binding arise not just from the complexity and dynamics of the lipidome, but also from the transient nature of protein lipid interactions.
To overcome these challenges we will take mass spectrometry (MS) into…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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