CORDIS Project
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This project investigates the role of a secreted enzyme, nicotinamide N-methyltransferase, in the immune environment of castration-resistant prostate cancer. By understanding how this enzyme influences immune cell interactions, the research aims to inform new immunotherapeutic strategies for treatment.
Prostate cancer (PC) is the most common male cancer in the United Kingdom and more effective treatments are needed to control the lethal late-stage disease, termed castration-resistant PC (CRPC).
CRPC is largely refractory to immunotherapeutic interventions mainly due to its tumour-immune microenvironment (TIME) with low infiltration of activated anti-tumour immune cells.Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme which catalyses the transfer of methyl groups from S-adenosylmet…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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United States, Princeton, Nj
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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