CORDIS Project
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This project explores a new method for stereospecific cross-coupling reactions using chiral alkyl boronates and electrophilic oxidants. It aims to create complex carbon-carbon bonds efficiently, enhancing the synthesis of enantiopure aromatic compounds through innovative chemical processes.
One of the most challenging aspects of Suzuki-Miyaura reactions is the stereospecific cross-coupling of sp3 substituted boronic esters with aryl halides.
Recently, the host group developed a metal-free, stereospecific cross-coupling reaction of chiral alkyl boronates with electron-rich aromatics, promoted by the use of electrophilic oxidants.
This proposal seeks to substantially extend this cross-coupling chemistry through the application of a range of different electrophiles that will not only…
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