CORDIS Project
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This research aims to uncover the molecular pathways that establish left-right asymmetry in embryos, focusing on the role of specific transcription factors. Understanding these processes could provide insights into developmental disorders and cancer progression.
The majority of animals show an external bilateral symmetry, precluding the observation of multiple internal left-right (L/R) asymmetries which are fundamental for organ packaging and function. A prominent molecular pathway converging on and downstream of the Pitx2 transcription factor confers left-handed information in the left side of the embryo, with players expressed on the right ensuring that the left determinants are excluded.
Therefore, conferring or excluding left identity in left and ri…
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
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