CORDIS Project
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This project investigates the mechanisms behind DNA double strand breaks during meiosis in yeast. It focuses on how histone modifications and chromatin structure influence the formation of these breaks, which are crucial for genetic recombination and diversity.
Meiotic recombination is initiated by programmed DNA double strand breaks (DSBs) catalysed by the evolutionary conserved Spo11 protein and associated factors.
In the yeast S. cerevisiae, the DSB sites are non-randomly distributed along the chromosomes: certain genomic regions have higher propensity to form DSBs than others, explaining the expansion and contraction of the genetic versus physical maps.
The cis- and trans-acting factors that select the DSB sites in the chromatin architecture and m…
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