CORDIS Project
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This project investigates the regulation of pancreatic cell composition during development, focusing on the role of extrinsic signals. Using a novel mouse model, it aims to identify how these signals influence cell proliferation and the formation of insulin-producing cells.
The pancreas constitutes of various cell types with distinctive function.
Exocrine cells produce and secrete digestive enzymes while endocrine cells, including insulin-producing beta-cells, secrete hormones that regulate glucose homeostasis.
The proportional quantity of the different pancreatic cell populations is well defined, when exocrine cells encompass majority of the tissue mass.
However, while the establishment of pancreas cellular composition during embryogenesis has been well acknowl…
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