CORDIS Project
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This project focuses on the role of exosomes in neuronal communication and their involvement in Alzheimer's disease. It aims to identify how protein aggregates affect exosome function and explore potential biomarkers for the disease.
Exosomes are small vesicles which mediate cell-cell communication by transporting across the extracellular environment specific “packages” of RNA and proteins.
Importantly, exosomes carry translation initiation factors (TIFs) and miRNAs, a class of short non-coding RNAs with regulatory activity on the expression of the transcriptome of a cell.
In the brain, exosome-delivered miRNAs and proteins are thought to be involved in the coordinated modulation of gene expression required for the long-term…
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