CORDIS Project
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This project aims to explore the three-dimensional structure of the genome during early mammalian development, particularly focusing on totipotency and pluripotency genes. Using advanced microscopy techniques, it seeks to understand how genomic architecture influences cell differentiation.
The three-dimensional architecture of the genome regulates its fundamental functions such as the transcription or replication of DNA.
Thus, chromatin organisation is crucially important for key aspects of cell biology, such as the differentiation of stem cells in the early embryo.
While recent studies have shown that the mammalian genome rearranges extensively towards a more ordered state after the first few embryonal divisions, many fundamental questions remain unanswered.
For example, it is no…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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