CORDIS Project
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This project utilizes NMR-based metabonomics to explore the metabolic factors influencing the differentiation of human embryonic stem cells. It aims to identify these factors and classify differentiated cell types, contributing to advancements in regenerative medicine.
Human Embryonic Stem Cells (hESCs) harbour the extraordinary ability to self-renew and differentiate into cells of all tissue types and thus, hold great promise for the treatment of a range of diseases.
Mechanisms controlling hESC fate are yet to be elucidated but are believed to involve regulation by intrinsic and extracellular metabolic factors including hormones, growth factors and small cell-permeable molecules.
High resolution proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy is a pow…
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