CORDIS Project
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This project investigates the role of liver macrophages, known as Kupffer cells, in processing intestinal antigens and modulating immune responses. By utilizing specialized mouse models, it aims to uncover mechanisms that could lead to new treatments for conditions like food allergies and inflammatory bowel diseases.
The liver is constantly exposed to intestinal material via portal blood circulation and thus it has long been implicated in the modulation of systemic immune responses to intestinal antigens.
Despite this, the precise cells involved and the molecular mechanisms at play are largely unknown.
Liver resident macrophages termed Kupffer cells (KCs) are ideally located within the blood stream of the liver sinusoids to encounter intestinal antigens.
We hypothesise that KCs acquire intestinal antigens an…
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