CORDIS Project
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This research focuses on the NOD2 receptor's role in immune responses, particularly in Crohn's disease. By investigating how NOD2 influences autophagy in immune cells, the project aims to identify potential targets for new treatments.
NOD2 is an intracellular pathogen recognition receptor (PRR) expressed in monocyte lineage and intestinal epithelial cells. NOD2 recognizes muramyldipeptide (MDP), a component of bacterial cell walls and MDP stimulation induces a signalling cascade that synergises with that of other PRRs to mature dendritic cells (DCs) and renders them competent for antigen presentation. NOD2 is notable in that variants of the receptor are associated with 40% of western Crohn’s (CD) disease.
Previously Dr Simmon…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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