CORDIS Project
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This project explores how mechanical properties of the cellular environment influence gene expression and cell behavior. By studying the role of specific proteins in response to mechanical strain, the research aims to uncover pathways that could inform cancer treatment strategies.
The mechanical properties of the cellular environment deeply influence cell fate and behavior.
Cells respond to outer forces not only through the rapid remodeling of their cytoskeleton, but also by implementing gene expression changes.
The Piccolo laboratory pioneered the notion that the transcriptional coactivators YAP and TAZ act independently of the Hippo pathway to activate gene expression in response to cytoskeletal tension.
Crucially, YAP/TAZ are the main effectors of the cellular response…
UNIVERSITA DEGLI STUDI DI PADOVA
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