CORDIS Project
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This project investigates the role of nuclear actin-related proteins in maintaining genomic integrity. By focusing on actin's function within chromatin remodeling complexes, the research aims to understand how actin influences DNA damage response and cellular stability.
Nuclear actin-related proteins (ARPs) are stoichiometric subunits of chromatin remodelers and specifically recognize and bind to (modified) histone proteins.
In the case of the chromatin modifiers INO80, SWR1 and NuA4, canonical monomeric actin is also an important constituent of these large macromolecular complexes and actively takes part in the remodeling reaction.
The main characteristic of actin, however, is its dynamic nature and its capacity to form polymeric actin filaments, which is tigh…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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