CORDIS Project
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This project aims to explore the mechanisms of sister chromatid cohesion during meiosis, focusing on how cohesin complexes maintain chromosome integrity over long periods. It seeks to understand the implications for genetic stability and birth defects.
Sister chromatid cohesion is essential for proper chromosome segregation.
Chromosome cohesion is mediated by cohesin complexes which form a ring-like structure that embraces replicated sister chromatids and hold them together until anaphase onset.
Although cohesin binds to DNA dynamically before S phase, cohesion is only established during DNA replication, which requires acetylation of cohesin complexes and subsequent recruitment of Sororin.
Sororin promotes cohesion establishment and cohesion m…
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