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The Elsα project investigates the early-stage formation of protein aggregates in Parkinson's disease using advanced techniques. By combining time-resolved X-ray scattering with computer simulations, it aims to reveal the molecular mechanisms behind the aggregation of alpha-synuclein, potentially leading to new therapeu…
Parkinson's disease (PD) affects 10 million people worldwide and is characterized by the abnormal accumulation of protein aggregates in neuronal cells.
Such aggregates are mainly composed of an intrinsically disordered protein called alpha-synuclein (α-syn).
Recent evidence suggests that the nucleation event driving α-syn aggregation might be initiated by liquid-liquid phase separation (LLPS).
Due to a lack of techniques able to look at the early-stage LLPS the link between α-syn aggregation and…
KOBENHAVNS UNIVERSITET
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